Molecular characterization of Rft1, a membrane protein associated with congenital disorder of glycosylation type 1N
Hirata, E., Sakata, K., Dearden, G.I., Menon, I., Chiduza, G.N., Menon, A.K. (2024) bioRxiv www.biorxiv.org/content/10.1101/2024.04.03.587922v1
Phospholipids are imported into mitochondria by VDAC, a dimeric beta barrel scramblase
Jahn, H., Bartoš, L., Dearden, G.I., Dittman, J.S., Holthuis, J.C.M., Vácha, R., Menon, A.K. (2023) Nature Communications 14:8115 https://www.nature.com/articles/s41467-023-43570-y
A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors
Menon, I., Sych, T., Son, Y., Morizumi, T., Lee, J., Ernst, O.P., Khelashvili, G., Sezgin, E., Levitz, J., Menon, A.K. (2023) J. Biol. Chem. https://www.jbc.org/article/S0021-9258(24)00025-5/fulltext
Insertases scramble lipids: Molecular simulations of MTCH2
Bartoš, L., Menon, A.K., Vácha, R. (2024) Structure https://www.cell.com/structure/fulltext/S0969-2126(24)00036-4
Credit card mechanism of phospholipid scrambling
Proposed by Pomorski, Menon (2006) to explain how a membrane protein translocates phospholipids (image by Adam Steinberg). Recent work on GPCR and TMEM16 scramblases supports this model.